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Träfflista för sökning "WFRF:(Stram DO) ;pers:(Muir K);pers:(Giles GG)"

Search: WFRF:(Stram DO) > Muir K > Giles GG

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  • Darabi, H, et al. (author)
  • Fine scale mapping of the 17q22 breast cancer locus using dense SNPs, genotyped within the Collaborative Oncological Gene-Environment Study (COGs)
  • 2016
  • In: Scientific reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 6, s. 32512-
  • Journal article (peer-reviewed)abstract
    • Genome-wide association studies have found SNPs at 17q22 to be associated with breast cancer risk. To identify potential causal variants related to breast cancer risk, we performed a high resolution fine-mapping analysis that involved genotyping 517 SNPs using a custom Illumina iSelect array (iCOGS) followed by imputation of genotypes for 3,134 SNPs in more than 89,000 participants of European ancestry from the Breast Cancer Association Consortium (BCAC). We identified 28 highly correlated common variants, in a 53 Kb region spanning two introns of the STXBP4 gene, that are strong candidates for driving breast cancer risk (lead SNP rs2787486 (OR = 0.92; CI 0.90–0.94; P = 8.96 × 10−15)) and are correlated with two previously reported risk-associated variants at this locus, SNPs rs6504950 (OR = 0.94, P = 2.04 × 10−09, r2 = 0.73 with lead SNP) and rs1156287 (OR = 0.93, P = 3.41 × 10−11, r2 = 0.83 with lead SNP). Analyses indicate only one causal SNP in the region and several enhancer elements targeting STXBP4 are located within the 53 kb association signal. Expression studies in breast tumor tissues found SNP rs2787486 to be associated with increased STXBP4 expression, suggesting this may be a target gene of this locus.
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  • Gusev, A, et al. (author)
  • Atlas of prostate cancer heritability in European and African-American men pinpoints tissue-specific regulation
  • 2016
  • In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 7, s. 10979-
  • Journal article (peer-reviewed)abstract
    • Although genome-wide association studies have identified over 100 risk loci that explain ∼33% of familial risk for prostate cancer (PrCa), their functional effects on risk remain largely unknown. Here we use genotype data from 59,089 men of European and African American ancestries combined with cell-type-specific epigenetic data to build a genomic atlas of single-nucleotide polymorphism (SNP) heritability in PrCa. We find significant differences in heritability between variants in prostate-relevant epigenetic marks defined in normal versus tumour tissue as well as between tissue and cell lines. The majority of SNP heritability lies in regions marked by H3k27 acetylation in prostate adenoc7arcinoma cell line (LNCaP) or by DNaseI hypersensitive sites in cancer cell lines. We find a high degree of similarity between European and African American ancestries suggesting a similar genetic architecture from common variation underlying PrCa risk. Our findings showcase the power of integrating functional annotation with genetic data to understand the genetic basis of PrCa.
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  • Result 1-10 of 18
Type of publication
journal article (18)
Type of content
peer-reviewed (18)
Author/Editor
Zheng, W. (18)
Brenner, H (18)
Giles, GG (18)Undo refine
Stram, DO (18)
Muir, K (18)Undo refine
Hopper, JL (17)
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Southey, MC (17)
Cox, A (17)
Arndt, V (17)
Kang, D. (16)
Dennis, J (16)
Shu, XO (16)
Hall, P (16)
Czene, K (16)
Lindblom, A (16)
Peterlongo, P (16)
Milne, RL (16)
Bolla, MK (16)
Matsuo, K (16)
Teo, SH (16)
Brauch, H (16)
Hamann, U (16)
Schmidt, MK (16)
Fasching, PA (16)
Beckmann, MW (16)
Wu, AH (16)
Lophatananon, A (16)
Couch, FJ (16)
Guenel, P (16)
Bojesen, SE (16)
Stegmaier, C (16)
Kosma, VM (16)
Lambrechts, D (16)
Chang-Claude, J (16)
Benitez, J. (15)
Wang, Q. (15)
Ito, H. (15)
Michailidou, K (15)
Margolin, S (15)
Orr, N (15)
Hartman, M (15)
Dunning, AM (15)
Broeks, A (15)
Shen, CY (15)
Sangrajrang, S (15)
Peto, J (15)
Burwinkel, B (15)
Truong, T (15)
Nordestgaard, BG (15)
Mannermaa, A (15)
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University
Karolinska Institutet (18)
Lund University (4)
Umeå University (3)
Uppsala University (2)
Language
English (18)
Research subject (UKÄ/SCB)
Medical and Health Sciences (6)

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